Akcea Therapeutics is a development and commercialisation company focused on transforming the lives of patients with serious cardiometabolic lipid disorders. Akcea has a robust portfolio of development-stage drugs covering multiple targets and diseases using advanced RNA-targeted antisense therapeutics. Akceaâ€™s most advanced drug, volanesorsen, is being developed to address two severe, rare, genetically defined lipid disorders, FCS and FPL. Based on positive results in the Phase 3 program, Akcea is preparing regulatory dossiers for volanesorsen for the treatment of FCS and conducting a Phase 3 study evaluating volanesorsen in patients with FPL. Akcea's drug pipeline includes three additional novel antisense drugs designed to address a number of lipid risk factors, including ApoC-III, triglycerides, Lp(a), and LDL-cholesterol. Akcea is continuing to assemble the global infrastructure to develop and commercialise the drugs in its pipeline. Akcea is a wholly owned subsidiary of Ionis Pharmaceuticals, Inc. and is located in Cambridge, Massachusetts.