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Apitope

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Apitope is a clinical stage biotech company that develops potential first-in-class antigen-specific immunotherapies targeting autoimmune diseases.

Apitope uses its novel, proprietary discovery platform to select and develop highly specific peptide-based therapeutics, known as "apitopes" (antigen processing independent epitopes), that directly target the immunological basis of autoimmune diseases, including multiple sclerosis (MS), Graves’ disease and uveitis, as well as undesired immune responses against biologic therapeutics used in the treatment of life-threatening disorders such as haemophilia A.

While current therapies for autoimmune diseases typically have the effect of suppressing the immune system, apitopes modulate only the malfunctioning part of the immune system in order to avoid such global immune suppression. The apitope mechanism of action and platform have the broad potential to treat a wide variety of autoimmune diseases. Apitope has a robust pipeline of innovative, potential first-in-class product candidates in clinical and pre-clinical development. Apitope’s lead product candidate ATX-MS-1467 is in development for the treatment of MS, and is ready to start a Phase IIb clinical trial.

Apitope was founded in 2002 by Professor David Wraith, as a spin-out from the University of Bristol. It is based in Diepenbeek, Belgium, which is home to Apitope's research and finance activities, and Chepstow, United Kingdom, where Apitope's development and commercialisation activities are located.

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